环境中偏二甲肼检测方法的研究进展

摘要/Abstract

摘要： 目的近年来,由于偏二甲肼在航天工业的广泛使用,偏二甲肼对人体健康的影响不可忽视。因此,如何准确高效的检测环境中偏二甲肼的残留已成为人们研究的热点,但偏二甲肼强还原性、易燃易爆,检测也较难。本文综述了近年来对环境中偏二甲肼检测方法的研究,详细介绍了液相色谱法、气相色谱法、质谱法、传感器法等不同检测方法的异同点,同时总结了不同方法的检出限、线性范围和回收率。

关键词: 偏二甲肼, 环境暴露, 检测方法

Abstract: ：In recent years,due to the wide use of 1,1-dimethylhydrazine（UDMH） in the aerospace industry,the its impact on human health cannot be ignored. Therefore,how to detect UDMH in the environment accurately and efficiently become a research hotspot. However,it is difficult to detect UDMH because of its strong reducibility and inflammability. The article reviews the research on the detection of UDMH in the environment in recent years,introduces the similarities and differences of different detection methods such as liquid chromatography,gas chromatography,mass spectrometry,and sensor method,as well as summarizes the limits of detection,linear range,and recoveries of different methods.

Key words: 1,1-dimethylhydrazine, Environment exposure, Detection methods

中图分类号:

R115

魏甜甜, 胡红芳, 曾浩, 邱洪杰. 环境中偏二甲肼检测方法的研究进展. [J]职业与健康, 2023, 39(5): 705-710.

WEI Tian-tian, HU Hong-fang, ZENG Hao, QIU Hong-jie. Research progress on detection methods of 1,1-dimethylhydrazine in environment. [J]OCCUPATION AND HEALTH, 2023, 39(5): 705-710.

参考文献

[1] MAKAROVSKY I,MARKEL G,DUSHNITSKY T,et al.Hydrazine--the space era agent[J].Isr Med Assoc J,2008,10(4):302-306.
[2] ZELNICK S D,MATTIE D R,STEPANIAK P C,et al.Occupational exposure to hydrazines:treatment of acute central nervous system toxicity[J].Aviat Space Envir Md,2003,74(12):1285-1291.
[3] NGUYEN H N,CHENOWETH J A,BEBARTA V S,et al.The toxicity,pathophysiology,and treatment of acute hydrazine propellant exposure:A systematic review[J].Mil Med,2021,186(4):319-326.
[4] MORRIS J K,WALD N J,SPRINGETT A L,et al.Occupational exposure to hydrazine and subsequent risk of lung cancer:50-Year Follow-Up[J].PLos One,2015,10(9):138-148.
[5] OSIPENKO S V,SMIRNOV R S,SMOLENKOV A D,et al.Highly sensitive determination of 1,1-dimethylhydrazine by high-performance liquid chromatography-tandem mass spectrometry with precolumn derivatization by phenylglyoxal[J].J Anal Chem,2017,71(13):1228-1232.
[6] SUSINSKIS I,MEKSS P,HMELNICKIS J,et al.Method development for the determination of 1,1-dimethylhydrazine by the high-performance liquid chromatography-mass spectrometry technique[J].Eur J Mass Spectrom,2018,24(4):352-359.
[7] ULYANOVSKII N V,KOSYAKOV D S,POKRYSHKIN S A,et al.Determination of 1,1-Dimethylhydrazine and its transformation products in soil by zwitterionic hydrophilic interaction liquid chromatography/tandem mass spectrometry[J].Chromatographia,2018,81(6):891-900.
[8] TIMCHENKO Y V,STANRIANIDI A N,SMOLENKOV A D,et al.A novel simple and sensitive approach for determination of 1,1-dimethylhydrazine in aqueous samples by high performance liquid chromatography with ultraviolet and tandem mass spectrometric detection after derivatization with unsubstituted aromatic aldehydes[J].Chemosphere,2021,280(2):1307-1347.
[9] IARTSEV S D,PYTSKII I S,ZENKEVICH I G,et al.Chromatographic and mass-spectrometric study of the surfaces of construction materials after contact with 1,1-dimethylhydrazine[J].J Anal Chem,2017,72(6):624-631.
[10] SMOLENKOV A D,RODIN I A,SMIRNOV R S,et al.Use of ion and ion-pair chromatography with mass spectrometric detection to determine unsymmetrical dimethylhydrazine and its transformation products[J].Mosc U Phys B,2012,67(5):229-235.
[11] HUANG D,LIU X,WANG X,et al.Investigation on the compositions of unsymmetrical dimethylhydrazine treatment with different oxidants using solid-phase micro-extraction-gas chromatography-mass spectrometer[J].Roy Soc Open Sci,2019,6(5):190-263.
[12] POPOV M S,ULYANOVSKII N V,KOSYAKOV D S,et al.Gaschromatography-mass spectrometry quantification of 1,1-dimethylhydrazine transformation products in aqueous solutions:Accelerated water sample preparation[J].Molecules,2021,26(19):43-57.
[13] ULYANOVSKII N V,LAKHMANOV D E,PIKOVSKOI I I,et al.Migration and transformation of 1,1-dimethylhydrazine inpeat bog soil of rocket stage fall site in Russian North[J].Sci Total Environ,2020,726(5):138-148.
[14] LIU M,OSTOVIC J,CHEN EX,et al.Hydrophilic interaction liquid chromatography with alcohol as a weak eluent[J].J Chromatogr A,2009,1216(12):2362-2370.
[15] KOSYAKOV D S,PIKOVSKOI I I,ULYANOVSKII N V,et al.Direct determination of hydrazine,methylhydrazine,and 1,1-dimethylhydrazine by zwitterionic hydrophilic interaction liquid chromatography with amperometric detection[J].Int J Environ An Ch,2017,97(4):313-329.
[16] POPOV M S,ULYANOVSKII N V,KOSYAKOV,et al.Application of Atmospheric Pressure Photoionization to the Determination of 1,1-Dimethylhydrazine Transformation Products by Liquid Chromatography/Mass Spectrometry[J].J Anal Chem,2020,75(13):1700-1707.
[17] RODIN I A,ANANEVA I A,SMOLENKOV A D,et al.Determination of the products of the oxidative transformation ofunsymmetrical dimethylhydrazine in soils by liquid chromatography/mass spectrometry[J].J Anal Chem,2010,65(13):1405-1410.
[18] KOSYAKOV D S,ULYANOVSKII N V,BOGOLITSYN K G,et al.Simultaneous determination of 1,1-dimethylhydrazine and products of its oxidative transformations by liquid chromatography-tandem mass spectrometry[J].Int J Environ An Ch,2014,94(12):1254-1263.
[19] BAKAIKINA N V,KENESSOV B,ULYANOVSKII N V,et al.Quantification of Transformation Products of Unsymmetrical Dimethylhydrazine in Water Using SPME and GC-MS[J].Chromatographia,2017,80(6):931-940.
[20] SHAO B,LI H,SHEN J,et al.Nontargeted Detection Methods for Food Safety and Integrity[J].Annu Rev Food Sci T,2019,10(1):12-55.
[21] MILYUSHIN A L,BIRIN K P,MATYUSHIN D D,et al.Isomeric derivatives of triazoles as new toxic decomposition productsof 1,1-dimethylhydrazine[J].Chemosphere,2019,217(8):95-99.
[22] AMOSOV A S,ULYANOVSKII N V,KOSYAKOV D S,et al.Simultaneous Determination of Hydrazine,Methylhydrazine,and 1,1-Dimethylhydrazine by High-Performance Liquid Chromatography with Pre- and Post-Column Derivatization by5-Nitro-2-Furaldehyde[J].J Anal Chem,2018,73(5):497-503.
[23] SMOLENKOV A D,CHERNOBROVKINA A V,SMIRNOV R S,et al.A sensitive chromatographic determination of hydrazines bynaphthalene-2,3-dialdehyde derivatization[J].Int J Environ An Ch,2013,93(12):1286-1295.
[24] SMIRNOV R S,SMOLENKOV A D,BOLOTNIK T A,et al.Precolumn derivatization with glyoxal as a new approach to the highly sensitive HPLC-UV determination of unsymmetrical dimethylhydrazine[J].J Anal Chem,2013,68(9):837-844.
[25] SMOLENKOV A D,SMIRNOV R S,RODIN I A,et al.Effect of sample preparation conditions on the determination of the total concentrations of unsymmetrical dimethylhydrazine in soils[J].J Anal Chem,2011,67(1):6-13.
[26] ULYANOVSKII N V,KOSYAKOV D S,POPOV M S,et al.Rapid quantification and screening of nitrogen-containing rocket fuel transformation products by vortex assisted liquid-liquid microextraction and gas chromatography high-resolution Orbitrap mass spectrometry[J].Microchem J,2021,171(12):106-128.
[27] ORAZBAYEVA D,KENESSOV B,PSILLAKIS E,et al.Determination of transformation products of unsymmetrical dimethyl hydrazine in water using vacuum-assisted headspace solid-phase microextraction[J].J Chromatogr A,2018,1555(4):30-36.
[28] ULYANOVSKII N V,LAKHMANOV D E,PIKOVSKOI I I,et al.Determination of transformation products of 1,1-dimethylhydrazine by gas chromatography-tandem mass spectrometry[J].J Anal Chem,2015,70(13):1553-6150.
[29] SOTNIKOV E E,MOSKOVKIN A S.Gas-chromatographic determination of 1,1-dimethylhydrazine in water[J].J Anal Chem,2006,61(2):129-132.
[30] ULYANOVSKII N V,KOSYAKOV D S,BOGOLITSYN K G,et al.Specific features of sample preparation upon chromatographic determination of 1,1-dimethylhydrazine and N-nitrosodimethylamine in peaty soils[J].Mosc U Phys B,2015,70(2):63-68.
[31] PONOMARENKO S A,SMOLENKOV A D,SHPIGUN O A,et al.Determination of 1,1-dimethylhydrazine and its decomposition products using ion-pair chromatography[J].Mosc U Phys B,2009,64(3):147-153.
[32] ZHOU F,REN XH,D U SY,et al.Direct Evaluation of Unsymmetrical Dimethylhydrazine with Wide Concentration Range in Wastewater by Ion Chromatography[J].Chromatographia,2019,83(1):107-113.
[33] KOSYAKOV D S,KHVIYUZOV S S,ULYANOVSKII N V,et al.Supercritical fluid extraction of 1,1-dimethylhydrazine from peaty soils[J].Russ J Phys Chem B,2014,7(7):880-884.
[34] POLVNIN K E,GONCHAROVA I S,POLUNINA I A,et al.Soft ionization mass spectrometry for studying desorption of bioactive compounds from a shungite surface[J].Colloid J,2017,79(2):250-257.
[35] IARTSEV S D,PYTSKII I S,PYTSKII I S,et al.Surface-assisted laser desorption/ionization mass spectrometry for the detection of low-molecular-weight and oligomeric products of 1,1-dimethylhydrazine transformation on the surfaces of construction materials[J].Russ J Phys Chem B,2017,11(4):680-683.
[36] KOSYAKOV D S,ULYANOVSKII N V,PIKOVSKOI I I,et al.Effects of oxidant and catalyst on the transformation products of rocket fuel 1,1-dimethylhydrazine in water and soil[J].Chemosphere,2019,2286(6):335-344.
[37] SMIRNOV A V,PANTELEYEV M A,KRIVETSKTY V V,et al.Catalytic oxidation of unsymmetrical dimethylhydrazine on Pt/SiO₂[J].Russ J Appl Chem,2016,89(7):1109-1118.
[38] SOBHANMANESH B,NAJAFI M.Selective determination of unsymmetrical dimethylhydrazine on a prussian blue modified carbon paste electrode[J].J Brazil Chem Soc,2014,26(3):451-457.
[39] DEY A.Semiconductor metal oxide gas sensors:A review[J].Mat Sci Eng B-Adv,2018,229(12):206-117.
[40] FRATODDI I,VENDITTI I,CAMETTI C,et al.Chemiresistive polyaniline-based gas sensors:A mini review[J].Sensor Actuat B-Chem,2015,220(6):534-548.
[41] PIRSA S,KHANI A.Fabrication of 1,1-Dimethylhydrazine gas sensor based on nano structure conducting polyaniline[J].J Sci I R I,2013,24(3):209-215.
[42] GUO L,MATYSIK F M,GLASER P,et al.Determination of hydrazine,monomethylhydrazine,1,1-dimethylhydrazine,and 1,2-dimethylhydrazine by nonaqueous capillary electrophoresis with amperometric detection[J].Electrophoresis,2005,26(17):3341-3348.
[43] KAILASA S K,KODURU J R,DESAI M L,et al.Recent progress on surface chemistry of plasmonic metal nanoparticles for colorimetric assay of drugs in pharmaceutical and biological samples[J].Trends Environ Anal,2018,105(6):106-120.
[44] YAO X,ZHANG G Y,LIU B,et al.Direct detection of 1,1-dimethylhydrazine in water samples based on formation of gold nanoparticles[J].Mater Res Express,2019,6(6):57-65.
[45] MININ V V,OSTROVSKAYA V M,AVDEEVA V V,et al.Radical indicator reaction for determination of 1,1-dimethylhydrazine[J].Talanta,2019,195(4):599-603.