Abstract: Objective To analyze the disease burden and change trend of colorectal cancer among registered residence residents in Chaoyang District of Beijing from 2003 to 2022,and to provide data support and scientific basis for formulating colorectal cancer prevention and control strategies suitable for Chaoyang District. Methods The death registration data of registered residence residents in Chaoyang District of Beijing from 2003 to 2022 were used to analyze the crude mortality,standardized mortality,years of life lost（YLL）,years of lived with disability（YLD）,disability-adjusted life years（DALY） and their average annual percent change（AAPC） of colorectal cancer in the integrated analysis platform of health and disease prevention monitoring information resources in Beijing. Excel 2016,SPSS 17.0 and Joinpoint Regression Program（version 4.6.0.0） were used for statistical analysis. Results From 2003 to 2022,there were a total of 7 764 deaths from colorectal cancer among residents in Chaoyang District of Beijing,and the crude mortality increased from 10.78/100 000 to 26.75/100 000（AAPC=5.29%,P<0.01）. The crude death rate,standardized death rate of male and crude death rate of female showed an increasing trend（AAPC=5.69%,0.97%,3.71%,all P<0.01）. The number of deaths,crude mortality rate,and standardized mortality rate of colorectal cancer in male were higher than those in female. The mortality rate of both males and females age ≥75 showed an upward trend（AAPC=3.07%,2.08%,all P<0.01）. The mortality rate of males aged 45-<60 was is on the rise（AAPC=1.82%,P<0.05）. The YLL rate,YLD rate and DALY rate of colorectal cancer showed an upward trend（AAPC=3.71%,6.67%,3.80%,all P<0.01）. The YLL rate,YLD rate and DALY rate,and their rate of increase in males were higher than those in females. The proportion of DALY among residents aged 45-<60 and 60-<75 in the entire age group was 21.96 and 40.76%,respectively. Conclusion The mortality rate,standardized mortality rate and DALY rate of colorectal cancer among residents in Chaoyang District of Beijing from 2003 to 2022 showed an upward trend,especially among males and the elderly,whose disease burden was becoming increasingly severe. The government should conduct health education for the whole population,promote healthy eating habits and lifestyles,and increase early screening of colorectal cancer,especially for high-risk groups,so as to achieve early detection,early diagnosis and early treatment,and reduce the disease burden of colorectal cancer.

Key words: Colorectal cancer, Mortality, Disease burden, Disability adjusted life years, Average annual percent change