8-羟基脱氧鸟苷与职业接触抗肿瘤药物者健康效应的研究进展

摘要/Abstract

摘要： 8-羟基脱氧鸟苷是氧化应激引起 DNA 损伤的主要产物,在一定程度上反映 DNA 氧化损伤程度。8-羟基脱氧鸟苷的产生、代谢机制与机体疾病、肿瘤的发生密不可分,抗肿瘤药物是一种能引起 DNA 氧化损伤的有毒化学物质,长期职业接触抗肿瘤药物者存在潜在健康损害。本文通过对 8-羟基脱氧鸟苷产生代谢机制、与抗肿瘤药物的内在联系、与机体肿瘤的关系以及职业接触者机体健康效应等进行综述,以期达到早期监测抗肿瘤药物职业接触者健康状况的目的,提供早期预警,巩固肿瘤专科人才的发展。

关键词: 8-羟基脱氧鸟苷, 抗肿瘤药物, 职业接触, 健康效应, 机制

Abstract: The 8-hydroxydeoxyguanosine is the main product of DNA damage caused by oxidative stress,which reflects the degree of DNA oxidative damage to a certain extent. The generation and metabolic mechanism of 8-hydroxydeoxyguanosine is closely related to the occurrence of diseases and tumors. The antineoplastic drugs are toxic chemicals that can cause oxidative damage to DNA,and long-term occupational exposure to antineoplastic drugs may lead to potential health damage. This article review the metabolic mechanism of 8-hydroxydeoxyguanosine,the internal relations to antineoplastic drugs,the the relationship with tumor and health effects of people with occupational exposure,in order to achieve early detection of health status of people with occupational exposure,provide early warning,and consolidate the development of cancer specialists.

Key words: 8-hydroxydeoxyguanosine, Antineoplastic drugs, Occupational exposure, Health effects, Mechanism

中图分类号:

R181.3⁺1

李佳, 梅小红, 陈昌蕊, 尚振秋, 黄小红. 8-羟基脱氧鸟苷与职业接触抗肿瘤药物者健康效应的研究进展. [J]职业与健康, 2023, 39(9): 1278-1282.

LI Jia, MEI Xiao-hong, CHEN Chang-rui, SHANG Zhen-qiu, HUANG Xiao-hong. Research progress on 8-hydroxydeoxyguansine and health effects of people with occupational exposure to antineoplastic drugs. [J]OCCUPATION AND HEALTH, 2023, 39(9): 1278-1282.

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