天津市高氟暴露对高血糖患病的影响

职业与健康 ›› 2024, Vol. 40 ›› Issue (23): 3254-3258.

天津市高氟暴露对高血糖患病的影响

李文凤, 王洋, 张丹丹, 李芳, 段雅妮, 崔玉山

天津市疾病预防控制中心环境健康与公共卫生所,天津 300011

收稿日期:2024-05-30 修回日期:2024-08-09 出版日期:2024-12-01 发布日期:2026-04-09
通信作者: 崔玉山,副主任医师,E-mail：yushan.273@163.com
作者简介:李文凤,女,主管医师,主要从事地方病预防控制工作。
基金资助:
天津市卫生健康科技项目（TJWJ2022QN092）; 国家自然科学基金项目（82173641）; 天津市第二批卫生健康行业高层次人才选拔培养工程项目（TJSQNYXXR-D2-151）; 天津市医学重点学科（专科）建设项目流行病学（非传染病预防与控制）（TJYXZDXK-051A）

Impact of high fluoride exposure on hyperglycemia in Tianjin

LI Wenfeng, WANG Yang, ZHANG Dandan, LI Fang, DUAN Yani, CUI Yushan

Institute of Environmental and Public Health,Tianjin Center for Diseases Control and Prevention,Tianjin 300011,China

Received:2024-05-30 Revised:2024-08-09 Online:2024-12-01 Published:2026-04-09
Contact: CUI Yushan,Associate chief physician,E-mail：yushan.273@163.com

摘要/Abstract

摘要： 目的探讨高氟暴露对高血糖患病情况的影响,为氟中毒病区高血糖防治提供科学依据。方法 2021—2022年在天津市饮水型氟中毒地区随机选择成年人共826人进行问卷调查、健康检查和随机1次尿样、空腹血样检测,采用logistic回归分析高氟地区高血糖患病影响因素,并分析其间的交互作用。结果被调查对象高血糖检出率为22.88%,高氟地区和对照地区间高血糖检出率比较,差异有统计学意义（χ²=13.313,P<0.01）。单因素分析结果显示,高血糖患病率与高水氟暴露、超重肥胖、文化程度、被动吸烟、糖尿病家族史、高血压、尿氟水平、高胆固醇、高三酰甘油和血脂异常有关（均P<0.05）。多因素logistic回归分析显示,排除其他混杂因素后,高水氟暴露（OR=2.132,95%CI：1.423~3.194）、超重肥胖（OR=1.907,95%CI：1.288~2.823）、糖尿病家族史（OR=3.555,95%CI：2.048~6.170）、高血压（OR=1.455,95%CI：1.020~2.076）及血脂异常（OR=2.085,95%CI：1.469~2.959）是高血糖患病的危险因素。交互作用分析显示,高氟暴露与血脂异常对高血糖患病存在相乘交互作用（OR=0.468,95%CI：0.230~0.950,P<0.05）。结论高氟暴露有可能增加人群高血糖患病风险,其与血脂异常对高血糖患病存在相乘交互作用。

关键词: 高氟暴露, 高血糖, 影响因素, 交互作用

Abstract: Objective To explore the effect of high fluoride exposure on hyperglycemia,and to provide scientific basis for prevention and treatment of hyperglycemia in fluoride poisoning areas. Methods From 2021 to 2022,a total of 826 adults were randomly selected from drinking-water fluorosis areas in Tianjin to conduct questionnaire survey,physical examination,random urine samples and fasting blood sample testing. Logistic regression analysis was used to analyze the influencing factors of hyperglycemia in the high fluoride areas,and the interaction of related influencing factors was analyzed. Results The detection rate of hyperglycemia was 22.88%. There was a statistically significant difference in the detection rate of hyperglycemia between the high-fluoride area and the control area（χ²=13.313,P<0.01）. The results of univariate analysis showed that the prevalence of hyperglycemia was related to high fluorine exposure,overweight and obesity,education level,passive smoking,family history of diabetes,hypertension,urinary fluorine level,high cholesterol,high triglyceride and dyslipidemia（all P<0.05）. Multivariate logistic regression analysis showed that after excluding other confounding factors,high fluoride exposure（OR=2.132,95%CI：1.423-3.194）,overweight and obesity（OR=1.907,95%CI：1.288-2.823）,family history of diabetes（OR=3.555,95%CI：2.048-6.170）,hypertension（OR=1.455,95%CI：1.020-2.076） and dyslipidemia（OR=2.085,95%CI：1.469-2.959） were risk factors for hyperglycemia in adults. Interaction analysis showed that there was a multiplicative interaction between high fluoride exposure and dyslipidemia in the development of hyperglycemia（OR=0.468,95%CI：0.230-0.950,P<0.05）. Conclusion High fluoride exposure was likely to increase the risk of hyperglycemia,and there is a multiplicative interaction between it and dyslipidemia on hyperglycemia.

Key words: High fluoride exposure, Hyperglycemia, Influencing factors, Interaction

中图分类号:

R181.3⁺7

李文凤, 王洋, 张丹丹, 李芳, 段雅妮, 崔玉山. 天津市高氟暴露对高血糖患病的影响. [J]职业与健康, 2024, 40(23): 3254-3258.

LI Wenfeng, WANG Yang, ZHANG Dandan, LI Fang, DUAN Yani, CUI Yushan. Impact of high fluoride exposure on hyperglycemia in Tianjin. [J]OCCUPATION AND HEALTH, 2024, 40(23): 3254-3258.

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