红毛藻多糖片剂制备综合实验设计

职业与健康 ›› 2025, Vol. 41 ›› Issue (5): 617-621.

红毛藻多糖片剂制备综合实验设计

吴靖娜, 周碧盈, 丘英珊, 石惠芳, 苏筱, 苏海燕

厦门医学院药学院,福建厦门 361023

收稿日期:2024-06-07 修回日期:2024-06-25 发布日期:2025-12-17
作者简介:吴靖娜,女,副教授,主要从事海洋生物资源高值化利用研究工作。
基金资助:
厦门市教育科学“十四五”规划课题（22086）

Comprehensive experimental design of preparation of Bangia fusco-purpurea polysaccharide tablets

WU Jingna, ZHOU Biying, QIU Yingshan, SHI Huifang, SU Xiao, SU Haiyan

School of Pharmacy,Xiamen Medical College,Xiamen,Fujian 361023,China

Received:2024-06-07 Revised:2024-06-25 Published:2025-12-17

摘要/Abstract

摘要： 目的以红毛藻为原料制备片剂,建立红毛藻多糖片剂的评价方法。方法根据前期的科研成果以及生产实际需求,设计了“红毛藻多糖片剂制备综合实验”,以红毛藻多糖为主要原料,片剂外观、重量差异、硬度、脆碎度和崩解时限为评价指标,采用单因素和正交试验优化片剂制备工艺,并对红毛藻多糖片剂进行糖包衣改善其性能。结果获得红毛藻多糖片剂的最优配方：微晶纤维素（microcrystalline cellulose,MCC）37.25%,玉米淀粉37.25%,交联羧甲基纤维素钠（cross-linked sodium carboxymethyl cellulose,CC-Na）7%,硬脂酸镁0.3%,菊粉8.2%,红毛藻多糖10%;低场核磁检测表明糖包衣有利于增强片剂在储藏过程中的稳定性。结论所建立的红毛藻多糖片剂评价方法实验条件简单、结果可靠,适合红毛藻多糖片剂的评价。

关键词: 多糖, 片剂, 糖包衣, 正交优化

Abstract: Objective To prepare Bangia fusco-purpurea polysaccharide from Bangia fusco-purpurea,and establish an evaluation method for Bangia fusco-purpurea polysaccharide tablets. Methods According to previous scientific research achievements and actual production needs,a "comprehensive experiment on the preparation of Bangia fusco-purpurea polysaccharide tablets" was designed. The polysaccharide isolated from Bangia fusco-purpurea was used as the main raw material,the appearance,weight difference,hardness,fragility,and disintegration time of the tablets were used as evaluation indicators. The single-factor and orthogonal experiments were used to optimize the tablet preparation process,and a sugar coating was applied to the Bangia fusco-purpurea polysaccharide tablets to improve their properties. Results The optimal formula for Bangia fusco-purpurea polysaccharide tablets was found to be：microcrystalline cellulose（MCC） 37.25%,corn starch 37.25%,cross-linked sodium carboxymethyl cellulose（CC-Na） 7%,magnesium stearate 0.3%,inulin 8.2%,and Bangia fusco-purpurea polysaccharide 10%. The low-field nuclear magnetic resonance detection showed that sugar coating enhances the stability of the tablets during storage. Conclusion The established evaluation method for Bangia fusco-purpurea polysaccharide tablets has simple experimental conditions and reliable results,which is suitable for the evaluation of Bangia fusco-purpurea polysaccharide tablets.

Key words: Polysaccharide, Tablet, Sugar coating, Orthogonal optimization

中图分类号:

R944.4

吴靖娜, 周碧盈, 丘英珊, 石惠芳, 苏筱, 苏海燕. 红毛藻多糖片剂制备综合实验设计. [J]职业与健康, 2025, 41(5): 617-621.

WU Jingna, ZHOU Biying, QIU Yingshan, SHI Huifang, SU Xiao, SU Haiyan. Comprehensive experimental design of preparation of Bangia fusco-purpurea polysaccharide tablets. [J]OCCUPATION AND HEALTH, 2025, 41(5): 617-621.

参考文献

[1] 马红梅,马军,李珍,等.涉海专业微生物学实验的教学改革[J].海南热带海洋学院学报,2020,27(2):111-114.
[2] 吴靖娜,曾臻,陈永轩.《海洋制药学》课程思政体系的构建与实践[J].云南化工,2022,49(3):144-148.
[3] 周丹,韦雪娇.微生物资源开发学综合性实验的设计与教学实践——以微生物絮凝剂综合实验项目设计为例[J].贵州师范学院学报,2021, 37(12):20-26.
[4] 王成,张国建,刘文典,等.海洋药物研究开发进展[J].中国海洋药物,2019,38(6):35-68.
[5] WU J N,CHEN X T,QIAO K,et al.Purification,structural elucidation,and in vitro antitumor effects of novel polysaccharides from Bangia fusco purpurea[J].Food Sci Hum Well,2021,10(1):63-71.
[6] JIANG Z D,YU G,LIANG Y,et al.Inhibitory effects of a sulfated polysaccharide isolated from edible red alga Bangia fusco-purpurea on α-amylase and α-glucosidase[J].Biosci Biotech Bioch,2019,83(11):2065-2074.
[7] 张一非,陈艳红,伍菱,等.响应面优化红毛藻多糖提取工艺及抗光氧化活性[J].水产科学,2019,38(6):749-758.
[8] 余刚,蔡薇,宋田源,等.红毛藻多糖的化学组成及其体外免疫诱导活性研究[J].中国食品学报,2020,20(6):37-47.
[9] 詹慧,宋田源,余刚,等.基于酶活力模型和细胞模型分析红毛藻多糖降血脂活性[J].食品科学,2021,42(7):142-148.
[10] 潘欣妍. 显齿蛇葡萄多糖分离、鉴定及其片剂制备研究[D].大连:大连海洋大学,2019.
[11] 朱忠铠. 参麦多糖的提取、口服液的制备以及抗疲劳活性研究[D].成都:四川农业大学,2020.
[12] 张育贵,吴红伟,李东辉,等.甜荞多糖提取工艺的优化及其颗粒剂的制备[J].山西中医药大学学报,2020,21(3):187-191.
[13] 刘玉明,钱甜甜,蒋定文,等.海洋星虫多糖胶囊的制备及质量控制[J].中国海洋药物,2014,33(5):71-76.
[14] 王炫文. 牡蛎内脏多糖分离及牡蛎多糖片剂制备研究[D].大连:大连海洋大学,2018.
[15] 席晓志,郭弘,郭莎莎,等.洋参蒺藜多糖片的制备及其抗疲劳功能研究[J].中国食品添加剂,2018,29(2):67-72.
[16] HIEW T N,JOHAN N A B,DESAI P M,et al.Effect of moisture sorption on the performance of crospovidone[J].Int J Pharmaceut,2016, 514(1):322-331.
[17] 国家药典委员会.中华人民共和国药典.四部[M].北京:中国医药科技出版社,2020:1-3.
[18] 马飞燕. 药用MCC质量与其片剂应用性能的相关性研究[D].西安:陕西科技大学,2020.
[19] 敖玲玲,张晨芳,徐凯敏,等.几种常用崩解剂的理化性能和应用效果[J].中国医药指南,2015,13(16):20-22.
[20] 韩立柱,刘帝呈,胡坤霞,等.香菊片制备工艺的优化[J].中成药,2021,43(8):1995-2001.
[21] 吴靖娜,陈晓婷,苏永昌,等.基于低场核磁共振技术对不同干燥方式的海马品质研究[J].大连海洋大学学报,2021,36(3):495-501.
[22] 郝发义. 多组分食品防潮包装货架期的研究[D].无锡:江南大学,2016.