环境内分泌干扰物调控过氧化物酶体增殖物激活受体γ表达与转录激活的研究进展

职业与健康 ›› 2024, Vol. 40 ›› Issue (5): 711-715.

环境内分泌干扰物调控过氧化物酶体增殖物激活受体γ表达与转录激活的研究进展

曹亚强^1,2, 苗轲², 高旭², 俞建霞³, 许滋宁¹, 陈圆圆²

1.南通市疾病预防控制中心环放科,江苏南通 226007;
2.中国疾病预防控制中心环境与健康相关产品安全所环境与人群健康重点实验室,北京 100021;
3.南通市海门区第五人民医院,江苏南通 226100

收稿日期:2023-07-12 修回日期:2023-08-07 发布日期:2026-03-16
通信作者: 许滋宁,主治医师,E-mail：804999587@qq.com;陈圆圆,助理研究员,E-mail：chenyuanyuan@nieh.chinacdc.cn
作者简介:曹亚强,男,医师,主要从事环境卫生工作。
基金资助:
国家自然科学基金青年基金项目（22206178）

Research progress on regulation of environmental endocrine disrupting chemicals on the expressions and transactivation of peroxisome proliferator activated receptor γ

CAO Yaqiang^1,2, MIAO Ke², GAO Xu², YU Jianxia³, XU Zining¹, CHEN Yuanyuan²

1. Department of Environment and Radiology,Nantong Center for Disease Control and Prevention,Nantong Jiangsu,226007, China;
2. Key Laboratory of Environment and Population Health,National Institute of Environmental Health,Chinese Center for Disease Control and Prevention,Beijing,100021, China;
3. The Fifth People's Hospital of Haimen District,Nantong Jiangsu,226100, China

Received:2023-07-12 Revised:2023-08-07 Published:2026-03-16
Contact: XU Zining,Attending physician,E-mail：804999587@qq.com;CHEN Yuanyuan,Research assistant,E-mail：chenyuanyuan@nieh.chinacdc.cn

摘要/Abstract

摘要： 越来越多的实验和人群研究发现,环境内分泌干扰物（endocrine disrupting chemicals,EDCs）除了干扰免疫、神经和生殖等系统的正常功能,还能够影响机体正常脂质代谢。EDCs依赖过氧化物酶体增殖物激活受体γ（peroxisome proliferator activated receptor γ,PPARγ）介导脂肪分化是当前研究的热点。本文围绕PPARγ结构特征、生理功能,以及EDCs对PPARγ的表达调控进行综述,旨在为全面评估EDCs的健康风险提供参考。

关键词: 内分泌干扰物, 核受体, 脂质代谢, 肥胖

Abstract: Mounting evidence from experiment and population studies has shown that environmental endocrine chemicals（EDCs） can also affect the normal lipid metabolism of the body,in addition to interfere with the normal function of immune,nervous,reproductive and other systems.The peroxisome proliferator-activated receptor γ（PPARγ） mediated adipose differentiation is a hot topic in EDCs studies.In this review,the structural characteristics,physiological functions of PPARγ,and the regulation of PPARγ expression by EDCs were systemically introduced,intending to provide reference for a comprehensive assessment of the health risks of EDCs.

Key words: Endocrine disruptors chemicals, Nuclear receptor, Lipid metabolism, Obesity

中图分类号:

曹亚强, 苗轲, 高旭, 俞建霞, 许滋宁, 陈圆圆. 环境内分泌干扰物调控过氧化物酶体增殖物激活受体γ表达与转录激活的研究进展. [J]职业与健康, 2024, 40(5): 711-715.

CAO Yaqiang, MIAO Ke, GAO Xu, YU Jianxia, XU Zining, CHEN Yuanyuan. Research progress on regulation of environmental endocrine disrupting chemicals on the expressions and transactivation of peroxisome proliferator activated receptor γ. [J]OCCUPATION AND HEALTH, 2024, 40(5): 711-715.

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