环境内分泌干扰物暴露诱发神经功能改变的研究进展

职业与健康 ›› 2024, Vol. 40 ›› Issue (7): 983-987.

环境内分泌干扰物暴露诱发神经功能改变的研究进展

杨礼林, 俞捷, 许洁

遵义医科大学公共卫生学院,贵州遵义 563000

收稿日期:2023-06-23 修回日期:2023-08-07 出版日期:2024-04-01 发布日期:2026-03-16
通信作者: 许洁,教授,E-mail：649904039@qq.com
作者简介:杨礼林,男,在读硕士研究生,研究方向为环境与健康。
基金资助:
国家自然科学基金（22166035）; 贵州省高层次人才基金（黔科合平台人才[2020]6014）; 遵义市15851人才项目（2019-E262）

Research progress on neurofunctional changes induced by exposure to environmental endocrine disruptors

YANG Lilin, YU Jie, XU Jie

School of Public Health,Zunyi Medical University,Zunyi Guizhou,563000, China

Received:2023-06-23 Revised:2023-08-07 Online:2024-04-01 Published:2026-03-16
Contact: XU Jie,Professor,E-mail：649904039@qq.com

摘要/Abstract

摘要： 神经系统是机体内对生理功能活动的调节起主导作用的系统,当神经系统受损后,受损部分所负责的生理功能也会受到影响。研究表明,环境内分泌干扰物可对神经元正常结构和功能造成影响,从而导致神经功能改变。本文综述了几种有代表性的环境内分泌干扰物[双酚A、壬基酚、邻苯二甲酸二（2-乙基己基）酯、马拉硫磷]造成神经损伤的机制、与神经功能改变关系,以及多种环境内分泌干扰物混合物对神经系统复合作用,为维持神经功能稳定提供参考依据。

关键词: 环境内分泌干扰物, 神经系统, 神经毒性, 氧化应激

Abstract: The nervous system is the system that plays a dominant role in regulating physiological activities in the body. When the nervous system is damaged,the physiological functions responsible for the damaged parts will also be affected. Research has shown that environmental endocrine disruptors can affect the normal structure and function of neurons,leading to changes in neural function. This article reviews the mechanism of nerve damage caused by several representative environmental endocrine disruptors[bisphenol A,nonylphenol,di（2-ethylhexyl） phthalate,malathion],their relationship with changes in neural function,and the complex effects of various mixtures of environmental endocrine disruptors on the nervous system,providing reference for maintaining stable neural function.

Key words: Environmental endocrine disruptors, Nervous system, Neurotoxicity, Oxidative stress

中图分类号:

R181.3⁺4

杨礼林, 俞捷, 许洁. 环境内分泌干扰物暴露诱发神经功能改变的研究进展. [J]职业与健康, 2024, 40(7): 983-987.

YANG Lilin, YU Jie, XU Jie. Research progress on neurofunctional changes induced by exposure to environmental endocrine disruptors. [J]OCCUPATION AND HEALTH, 2024, 40(7): 983-987.

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