妊娠早期PM2.5多重环境暴露对孕妇甲状腺激素水平的影响

职业与健康 ›› 2024, Vol. 40 ›› Issue (8): 1102-1105.

妊娠早期PM_2.5多重环境暴露对孕妇甲状腺激素水平的影响

周婧¹, 代永慧², 史建勇³, 王琛琛⁴, 张玲⁴, 吴顺华¹

1.新疆医科大学公共卫生学院,新疆乌鲁木齐 830054;
2.博尔塔拉蒙古自治州人民医院产科,新疆博尔塔拉蒙古自治州 833400;
3.博尔塔拉蒙古自治州疾病预防控制中心办公室,新疆博尔塔拉蒙古自治州 833400;
4.新疆维吾尔自治区疾病预防控制中心健康危害因素检测与控制所,新疆乌鲁乌齐 830002

收稿日期:2024-02-28 修回日期:2024-03-02 出版日期:2024-04-15 发布日期:2026-03-16
通信作者: 吴顺华,二级教授,E-mail：wushunhua@126.com
作者简介:周婧,女,在读硕士研究生,研究方向为环境健康。
基金资助:
国家自然科学基金（82260648）; 国家卫生健康委病因流行病学重点实验室（哈尔滨医科大学）开放课题（NHCKLEE20230906）

Effect of multiple environmental exposure to PM_2.5 in early pregnancy on thyroid hormone levels in pregnant women

ZHOU Jing¹, DAI Yonghui², SHI Jianyong³, WANG Chenchen⁴, ZHANG Ling⁴, WU Shunhua¹

1. School of Public Health,Xinjiang Medical University,Urumqi Xinjiang,830054, China;
2. Obstetrics Department,Bortala Mongolian Autonomous Prefecture People's Hospital,Bozhou Xinjiang,833400, China;
3. Office Department,Disease Prevention and Control Center of Bortala Mongolian Autonomous Prefecture,Bozhou Xinjiang,833400, China;
4. Health Hazard Factor Detection and Control Institute,Xinjiang Uygur Autonomous Region Center for Disease Prevention and Control,Urumqi Xinjiang,830002, China;

Received:2024-02-28 Revised:2024-03-02 Online:2024-04-15 Published:2026-03-16
Contact: WU Shunhua,Junior professor,E-mail：wushunhua@126.com

摘要/Abstract

摘要： 目的了解妊娠早期不同环境下细颗粒物（fine particulate matter,PM_2.5）暴露与母体甲状腺激素水平之间的关系。方法 2023年5—6月,使用新疆维吾尔自治区博尔塔拉蒙古自治州逐日PM_2.5数据,通过Arcgis 10.8中克里金插值工具计算新疆145名母婴队列孕妇妊娠早期住址周围PM_2.5暴露浓度,再通过室内、外颗粒物浓度比值（I/0值）计算室内妊娠早期PM_2.5暴露浓度,最后按照不同环境暴露时间计算多重环境下妊娠早期PM_2.5暴露浓度,使用广义线性模型分析不同环境下妊娠早期PM_2.5暴露浓度与队列孕妇甲状腺激素水平之间的关系。结果 145名孕妇妊娠早期日均室外环境PM_2.5暴露浓度[M（P₂₅,P₇₅）]为37（27,39）μg/m³,日均室内环境PM_2.5暴露浓度为23（18,27）μg/m³;多重环境日均暴露量（average daily dose,ADD）最高PM_2.5暴露浓度为30（24,33）μg/m³,日均ADD最低PM_2.5暴露浓度为25（20,29）μg/m³。145名孕妇血清游离甲状腺素（free thyroxine,FT4）水平为13.2（12.0,14.4）pmol/L,血清游离三碘甲状腺素（serum free triiodothyronine,FT3）水平为4.5（4.1,4.8）pmol/L,促甲状腺激素（thyroid stimulating hormone,TSH）水平为2.13（1.02,2.13）μIU/mL。妊娠早期日均室外、室内、ADD（最高）、ADD（最低）环境PM_2.5暴露浓度均与孕期FT4水平存在相关性,OR（95%CI）分别为0.967（0.954~0.979）、0.969（0.957~0.980）、0.969（0.959~0.980）、0.969（0.957~0.980）（均P<0.05）。结论室外、室内、多重环境下PM_2.5妊娠早期暴露均与孕期FT4存在相关性,孕早期处于胎儿甲状腺尚未发育的特殊阶段,需重点关注母体甲状腺激素水平稳态失衡。

关键词: 细颗粒物, 多重暴露, 妊娠早期, 甲状腺激素

Abstract: Objective To study the relationship between fine particulate matter（PM_2.5） exposure and maternal thyroid hormone levels in different environments during early pregnancy. Methods Using daily PM_2.5 data from Bortala Mongolian Autonomous Prefecture of Xinjiang Uygur Autonomous Region,the PM_2.5 exposure concentration around the early pregnancy address of 145 maternal infant queue pregnant women in Xinjiang was calculated using the Kriging interpolation tool in Arcgis 10.8. The indoor PM_2.5 exposure concentration in the early pregnancy was calculated using the ratio of indoor and outdoor particulate matter concentration（I/0 value）. The PM_2.5 exposure concentration in multiple environments was calculated based on different environmental exposure times,and using a generalized linear model to analyze the relationship between PM_2.5 exposure concentration in early pregnancy and thyroid hormone levels in cohort pregnant women under different environments. Results The average daily outdoor exposure concentration of PM_2.5 in early pregnancy of 145 pregnant women M（P₂₅,P₇₅） was 37（27,39）μg/m³,the daily average indoor exposure concentration of PM_2.5 was 23（18,27）μg/m³. The maximum exposure concentration of PM_2.5 in the average daily dose（ADD） of multiple environments was 30（24,33）μg/m³,the minimum exposure concentration of PM_2.5 was 25（20,29）μg/m³. 145 pregnant women had free thyroxine（FT4） levels of 13.2（12.0,14.4）pmol/L,serum free triiodothyronine（FT3） level was 4.5（4.1,4.8）pmol/L,thyroid stimulating hormone（TSH） level was 2.13（1.02,2.13）μIU/mL. The daily average outdoor,indoor,ADD （highest）,and ADD（lowest） environmental PM_2.5 exposure concentrations in early pregnancy were all correlated with FT4 levels during pregnancy,with OR（95%CI） of 0.967（0.954-0.979）,0.969（0.957-0.980）,0.969（0.959-0.980） and 0.969（0.957-0.980）,respectively（all P<0.05）. Conclusion Exposure to PM_2.5 in outdoor,indoor,and multiple environments during early pregnancy is correlated with FT4 during pregnancy. Early pregnancy is a special stage where the fetal thyroid gland has not yet developed,and should pay special attention to the imbalance of maternal thyroid hormone levels.

Key words: Fine particulate matter, Multiple exposures, Early pregnancy, Thyroid hormone

中图分类号:

R122.7

周婧, 代永慧, 史建勇, 王琛琛, 张玲, 吴顺华. 妊娠早期PM_2.5多重环境暴露对孕妇甲状腺激素水平的影响. [J]职业与健康, 2024, 40(8): 1102-1105.

ZHOU Jing, DAI Yonghui, SHI Jianyong, WANG Chenchen, ZHANG Ling, WU Shunhua. Effect of multiple environmental exposure to PM_2.5 in early pregnancy on thyroid hormone levels in pregnant women. [J]OCCUPATION AND HEALTH, 2024, 40(8): 1102-1105.

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