生物材料中苯系物及其代谢物检测方法的研究进展

摘要/Abstract

摘要： 苯系物（benzene,toluene,ethylbenzene,and xylenes,BTEX）及其代谢物检测分析在急、慢性苯系物中毒、职业病诊断和生物监测等方面发挥着重要作用。发展精准检测痕量和接近阈值苯系物及其代谢物的技术,解决检测生物材料中复杂基质的新型前处理技术成为目前需要解决的问题之一。目前国内外常见的检测方法有气相色谱-质谱联用、液相色谱、液相色谱-串联质谱等,本文重点综述了这些检测方法在血液和尿液中各种常见及新型的前处理技术,如液-液萃取、吹扫捕集法、动态顶空针头捕集法、电膜萃取、顶空固相微萃取、FaUMEx提取、同位素内标稀释法、固相萃取等以及苯系物及其代谢物检测方面的研究进展。

关键词: 生物材料, 苯系物及其代谢物, 检测方法, 研究进展

Abstract: The detection and analysis of benzene,toluene,ethylbenzene,and xylenes（BTEX） and their metabolites play an important role in acute and chronic benzene poisoning,occupational disease diagnosis and biological monitoring. One of the problems to be solved is to develop techniques for the accurate detection of trace amounts and near-threshold benzene series and their metabolites,and to solve new pretreatment techniques for the detection of complex matrices in biomaterials. At present,the common detection methods at home and abroad include gas chromatography-mass spectrometry,liquid chromatography,liquid chromatography-tandem mass spectrometry,etc. This article mainly reviews the research progress of the common and new pretreatment technologies of these detection methods in blood and urine,such as liquid-liquid extraction,purge and trap method,dynamic headspace needle capture method,electric membrane extraction,headspace solid phase microextraction,FaUMEx extraction,isotope internal standard dilution method,solid phase extraction,and benzene series and their metabolites detection.

Key words: Biomaterials, Benzene series and its metabolites, Detection method, Research progress

中图分类号:

R-115

高金龙, 赵翊, 王玉霞, 李拥军, 刘娅坤. 生物材料中苯系物及其代谢物检测方法的研究进展. [J]职业与健康, 2025, 41(14): 2002-2008.

GAO Jinlong, ZHAO Yi, WANG Yuxia, LI Yongjun, LIU Yakun. Research progress on detection methods of benzene series and their metabolites in biomaterials. [J]OCCUPATION AND HEALTH, 2025, 41(14): 2002-2008.

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