我国老年人群HIV-1分子亚型的地理分布和时间变化的meta分析

摘要/Abstract

摘要： 目的分析中国老年人群HIV-1分子亚型的地理和时间变化情况,为制定针对性防控措施提供科学依据。方法检索Pubmed、ScienceDirect、Web of Science、中国知网、万方等数据库2024年8月12日前发表的所有相关研究文献,利用meta分析方法估计老年人群HIV-1分子亚型的合并比例。用采样地区和采样时间段进行亚组分析,应用Begger’s和Egger’s检验评价发表偏倚,用敏感性分析评估合并比例的稳定性。结果本研究共纳入39篇文献,CRF01_AE,CRF07_BC和CRF08_BC为我国老年人群中分布最多的3种亚型。CRF01_AE的合并比例为37.5%（95%CI：30.8%~44.1%）,CRF07_BC的合并比例为28.3%（95%CI：22.6%~34.1%）,CRF08_BC的合并比例为21.0%（95%CI：17.2%~24.8%）。亚组分析发现,2016年及以前我国老年人群中CRF01_AE亚型的占比最高,随着时间推移比例逐渐下降,2021年及以后,CRF07_BC和CRF08_BC亚型占比均超过CRF01_AE,以CRF08_BC亚型最高;我国东部地区以CRF07_BC亚型占比最高,而西部和中部地区以CRF01_AE占比最高。结论我国老年人群HIV-1流行株分子亚型呈现复杂多样性,不同地区各亚型比例随着时间变化特征不同,有必要进一步加强对≥50岁人群的分子流行病学监测,降低艾滋病传播风险。

关键词: HIV-1, 老年人群, 分析亚型, Meta分析

Abstract: Objective To analyze the geographical and temporal changes of HIV-1 molecular subtypes in Chinese elderly population,and provide scientific basis for formulating targeted prevention and control measures. Methods Retrieve all relevant research literature published in databases such as Pubmed,ScienceDirect,Web of Science,CNKI,and Wanfang before August 12,2024,and use meta-analysis to estimate the combined proportion of HIV-1 molecular subtypes in the elderly population. Subgroup analysis was arranged by sampling area and time period,publication bias was evaluated by Begger's and Egger's test,and the stability of merger ratio was evaluated by sensitivity analysis. Results A total of 39 articles were included in this study,and CRF01_AE,CRF07_BC and CRF08_BC were the three most widely distributed subtypes in the elderly population in China. The merger ratio of CRF01_AE was 37.5%（95%CI：30.8%-44.1%）,CRF07_BC was 28.3%（95%CI：22.6%-34.1%）,and CRF08_BC was 21.0%（95%CI：17.2%-24.8%）. Subgroup analysis showed that the proportion of CRF01_AE subtype was the highest among the elderly in China in 2016 and before,and the proportion gradually decreased over time. After 2021,the proportion of CRF07_BC and CRF08_BC subtypes were higher than that of CRF01_AE,and the highest was CRF08_BC subtype. The proportion of CRF07_BC subtypes in the eastern part of China was the highest,while the proportion of CRF01_AE in the western and central regions was the highest. Conclusion The molecular subtypes of HIV-1 epidemic strains in the elderly in China are complex and diverse,and the proportion of each subtype changes with time in different regions. It is necessary to further strengthen the molecular epidemiological monitoring of people aged 50 and above to reduce the risk of AIDS transmission.

Key words: HIV-1, Elderly population, Analyze subtypes, Meta-analysis

中图分类号:

R181.2

范晓汨, 李宁丽. 我国老年人群HIV-1分子亚型的地理分布和时间变化的meta分析. [J]职业与健康, 2025, 41(19): 2702-2708.

FAN Xiaomi, LI Ningli. Meta-analysis of the geographic distribution and temporal trend of HIV-1 molecular subtypes in the elderly population of China. [J]OCCUPATION AND HEALTH, 2025, 41(19): 2702-2708.

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