Research progress on the mechanism and staged diagnosis and treatment of carbon disulfide poisoning with traditional Chinese medicine

Abstract

Abstract:

Carbon disulfide（CS₂） poisoning can lead to multiple system damages，including neurological dysfunction，microcirculatory disorders，and oxidative-inflammatory imbalances. Current treatment methods have limitations，and traditional Chinese medicine （TCM） has shown unique advantages and potential in the prevention and treatment of CS₂ poisoning. This article systematically reviews the application of TCM in the prevention and treatment of CS₂ poisoning，covering strategies such as using calamus and polygala to promote synaptic regeneration，tonifying herbs to improve mitochondrial function，and herbal enemas or nasogastric administration to clear blood toxins，as well as the synergistic effects of vitamin B complex and Danshen injection. Clinical studies and mechanism analysis have confirmed that TCM can effectively reduce poisoning damage by activating the brain-derived neurotrophic factor（BDNF） signaling pathway，regulating oxidative-inflammatory homeostasis，and improving microcirculation at multiple targets. However，the research highlights challenges in translational medicine，such as the complexity of TCM compound components，insufficient evidence-based support，and the lack of standards for integrating TCM and Western medicine. Related research proposes innovative directions，including using systems biology to analyze mechanisms，conducting multicenter clinical trials，leveraging cutting-edge technologies to simulate synergistic effects，and developing personalized treatment plans through big data，aiming to promote deeper application and theoretical development of TCM in the prevention and treatment of CS₂ poisoning.

Key words: Carbon disulfide poisoning, Traditional Chinese medicine intervention, Mechanism of action, Translational medicine, Innovative research, Staging diagnosis-treatment

CLC Number:

R135

HU Jiaxu, MENG Xuejiao, TU Lei. Research progress on the mechanism and staged diagnosis and treatment of carbon disulfide poisoning with traditional Chinese medicine. [J]OCCUPATION AND HEALTH, 2026, 42(14): 2002-2006.

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