Objective To understand the mediating role of work engagement in the relationship between psychological climate and job burnout among oncology nurses,and to provide a basis for improving nurses' psychological climate and alleviating job burnout. Methods A convenience sampling method was used to select 284 oncology nurses from six tertiary hospitals in Beijing City as the survey subjects from March and May 2024. The participants were surveyed using a general information questionnaire,the Chinese version of the brief psychological climate scale,the Utrecht work engagement scale,and the Oldenburg burnout inventory,and the data were analyzed. Results The total psychological climate score of oncology nurses was (11.24±4.26)points,work engagement score was (59.85±9.83)points,and job burnout score was (45.01±5.53)points. There was a positive correlation between psychological climate and work engagement(r=0.558,P<0.01),both psychological climate and work engagement were negatively correlated with job burnout(r=-0.452,-0.564,both P<0.01). Work engagement partially mediated the impact of psychological climate on job burnout among oncology nurses,with a mediating effect of 0.327,accounting for 55.81% of the total effect. Conclusion Work engagement mediates the relationship between psychological climate and job burnout among oncology nurses. Enhancing the level of work engagement may help improve their psychological climate and reduce the level of job burnout.