阻燃剂与农药联合暴露致甲状腺癌的初步分析

职业与健康 ›› 2023, Vol. 39 ›› Issue (18): 2482-2485.

阻燃剂与农药联合暴露致甲状腺癌的初步分析

李丹丹¹, 孙琳², 王天毅²

1.青岛市疾病预防控制中心,青岛市预防医学研究院环境卫生所,山东青岛 266033;
2.康复大学青岛医院（青岛市市立医院）心外科,山东青岛 266001

收稿日期:2023-04-05 修回日期:2023-05-08 出版日期:2023-09-15 发布日期:2026-03-25
通信作者: 王天毅,主治医师,E-mail：hank.titan@163.com
作者简介:李丹丹,女,主管医师,主要从事环境毒理学方向研究工作。
基金资助:
山东省医药卫生科技发展计划项目（202212010053）; 青岛市医药卫生科研计划项目（2021-WJZD160）

Preliminary analysis of thyroid cancer caused by combined exposure of flame retardants and pesticides

LI Dandan¹, SUN Lin², WANG Tianyi²

1. Department of Environmental Health of Qingdao Institute of Preventive Medicine,Qingdao Centers for Disease Control and Prevention,Qingdao Shandong 266033,China;
2. Cardiac Surgery,University of Health Rehabilitation Sciences,Qingdao Shandong 266033,China

Received:2023-04-05 Revised:2023-05-08 Online:2023-09-15 Published:2026-03-25
Contact: WANG Tianyi,Attending physician,E-mail：hank.titan@163.com

摘要/Abstract

摘要： 目的从基因水平探讨阻燃剂与农药联合暴露致甲状腺癌可能的生物联合作用机制。方法通过比较毒理基因组学数据库（comparative toxicogenomics database ,CTD）中获取阻燃剂与农药有确切证据的甲状腺癌相关基因,对阻燃剂与农药共同基因进行基因富集分析,获取共同基因/蛋白可能参与的生物进程或信号通路。结果经分析共同作用关键基因61个,这些基因分别参与激素代谢过程、对有毒物质的反应、对无机物的反应、细胞对脂质的反应、细胞对激素刺激的反应等GO生物学进程和AMPK信号通路。结论阻燃剂和农药主要通过肝微粒体酶P450酶系相关基因联合作用影响甲状腺激素水平,引起机体内分泌紊乱造成甲状腺功能改变,从而导致甲状腺癌的发生

关键词: 阻燃剂, 农药, 肝微粒体酶P450酶系, 甲状腺癌

Abstract: Objective To explore the possible biological mechanisms of combined exposure of flame retardants and pesticides to thyroid cancer at the genetic level. Methods Thyroid cancer related genes with clear evidence of flame retardants and pesticides were obtained from the comparative toxicogenomics database（CTD）. Gene enrichment analysis was performed on the common genes of flame retardants and pesticides to obtain the biological processes or signaling pathways that the common genes/proteins may be involved in. Results The results showed that 61 key genes were involved in the process of hormone metabolism,response to toxic substances,response to inorganic substances,cell response to lipids,cell response to hormone stimulation,and other GO biological processes and AMPK signaling pathways. Conclusion Flame retardants and pesticides mainly affect thyroid hormone levels through the combined action of liver microsomal enzyme P450 related genes,causing endocrine disorders and thyroid function changes,leading to the occurrence of thyroid cancer.

Key words: Flame retardants, Pesticides, Liver microsomal enzyme P450, Thyroid cancer

中图分类号:

R114

李丹丹, 孙琳, 王天毅. 阻燃剂与农药联合暴露致甲状腺癌的初步分析. [J]职业与健康, 2023, 39(18): 2482-2485.

LI Dandan, SUN Lin, WANG Tianyi. Preliminary analysis of thyroid cancer caused by combined exposure of flame retardants and pesticides. [J]OCCUPATION AND HEALTH, 2023, 39(18): 2482-2485.

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