关键词: 固相萃取, 超高效液相色谱-串联质谱, 农药, 生活饮用水, 出厂水

Abstract: Objective To establish a method for the determination of 86 pesticides in drinking factory water by solid phase extraction（SPE）-ultra high performance liquid chromatography tandem mass spectrometry（UPLC-MS/MS）. Methods According to the domestic and foreign drinking water sanitation standards,combined with the use of pesticides in China and the applicability of detection methods,86 pesticides were selected as the target analytes. The water sample pretreatment method and the multi-ion reaction monitoring（MRM） conditions of pesticides were optimized for method evaluation,and applied to the detection of pesticide residues in local factory water. Results The linear relationship of 86 pesticides within the range of 0.5-100 μg/L was good,with a correlation coefficient of 0.991 3-0.999 7,and a detection limit of 0.1-5.0 ng/L. The limit of quantification（LOQ） of 36 pesticides was 1 ng/L,29 pesticides was 2 ng/L,and 21 pesticides was 5 ng/L. The recovery rates of 86 pesticides at LOQ and above spiking levels were 59.5%-116.1%,and the relative standard deviations were 1.6%-40.1%. Conclusion This method is accurate and sensitive,and is suitable for the simultaneous detection of multiple types of pesticide residues in drinking water after actual sample testing.

Key words: Solid phase extraction, Ultra high performance liquid chromatography-tandem mass spectrometry, Pesticides, Drinking water, Factory water