职业人群幽门螺杆菌感染与血脂异常的相关研究

摘要/Abstract

摘要： 目的了解职业人群幽门螺杆菌（helicobacter pylori,HP）感染状况,探讨职业人群HP感染与血脂异常的相关性。方法收集2020年7月—2021年6月在武汉市职业病防治院参与HP筛查的1 799名职业健康检查人员的基本资料与实验室检测结果进行综合分析。在HP感染者中按年龄、性别分层抽样选取92例为A组,在1 799名职业健康检查者中选取95例未感染HP且健康状况良好的研究对象为B组,统计分析收缩压（systolic blood pressure,SBP）、舒张压（diastolic blood pressure,DBP）、体质指数（body mass index,BMI）、血清三酰甘油（triglycerides ,TG）、总胆固醇（cholesterol,TC）、高密度脂蛋白-胆固醇（high-density lipoprotein cholesterol,HDL-C）、低密度脂蛋白-胆固醇（low-destiy lipoprotein cholesterol,LDL-C）、肌酐（creatinine,CR）、尿酸（uric acid,UA）、空腹血糖（fasting plasma glucose,FBG）、丙氨酸氨基转移酶（alanine aminotransferase,ALT）、天门冬氨酸氨基转移酶（asparagine aminotransferase,AST）、血小板（platelet,PLT）、血小板分布宽度（platelet distribution width,PDW）。结果 1 799名职业健康检查者中HP感染阳性559例,感染率31.07%,不同性别、年龄的感染率比较,差异均无统计学意义（均P>0.05）。在1 799名职业健康检查者中血脂异常者475例,血脂异常率26.40%,男女血脂异常率分别是28.64%和21.02%,差异有统计学意义（P<0.05）。在475例血脂异常者中,混合型男性血脂异常率为14.29%,混合型女性血脂异常率为24.32%,混合型血脂异常情况男女患病比较,差异有统计学意义（P<0.05）。在475例血脂异常者中,HP感染者占35.78%,HP感染阳性且血脂混合型异常占血脂异常且HP阳性总数的9.41%,HP阴性且血脂混合型异常占血脂异常且HP阴性总数的20.66%,差异有统计学意义（P<0.05）。A组BMI、SBP、TG、TC、LDL-C、FBG、UA水平高于B组,差异均有统计学意义（均P<0.05）。多因素logistic回归分析结果显示,TC、UA的升高可能是HP感染的影响因素（均P<0.05）。结论职业健康检查人群HP感染率、血脂异常率较高,HP感染与血脂异常密切相关,应做好相关疾病的联合防控管理。

关键词: 职业人群, 幽门螺杆菌, 血脂异常, 相关性

Abstract: Objective To understand Helicobacter pylori（HP） infection in occupational population,explore the correlation between HP infection and dyslipidemia in occupational population. Methods The basic data and laboratory test results of 1 799 occupational health examinees who participated in HP screening in Wuhan Prevevention and Treatment Center for Occupational Diseases from July 2020 to June 2021 were collected and analyzed comprehensively. 92 patients with HP infection were selected by stratified sampling according to age and sex as group A. Among 1799 occupational health examinees,95 healthy subjects who were not infected with HP were selected as group B. The systolic blood pressure（SBP）,diastolic blood pressure（DBP）,body mass index（BMI）,serum triglycerides（TG）,totalcholesterol（TC）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,creatinine（CR）,uric acid（UA）,fasting plasma glucose（FBG）,alanine aminotransferase（ALT）,asparagine aminotransferase（AST）,platelet （PLT） and platelet distribution width （PDW） were statistically analyzed. Results Among the 1 799 occupational health examinees,559 cases were positive for HP infection,with an infection rate of 31.07%. There were no statistically significant differences in the infection rate among different genders and ages（all P>0.05）. Among the 1 799 occupational health examinees,there were 475 cases with dyslipidemia,with a dyslipidemia rate of 26.40%. The dyslipidemia rate of males and females was 28.64% and 21.02% respectively,and the difference was statistically significant（P<0.05）. Among 475 patients with dyslipidemia,the mixed male dyslipidemia rate was 14.29%,and the mixed female dyslipidemia rate was 24.32%. There was a statistically significant difference in the prevalence of mixed dyslipidemia between men and women（P<0.05）. Among 475 patients with dyslipidemia,those with HP infection accounted for 35.78%. The patients with positive HP and mixed dyslipidemia accounted for 9.41% of the total patients of dyslipidemia and positive HP,while the patients with negative HP and mixed dyslipidemia accounted for 20.66% of the total patients of dyslipidemia and negative HP,and the difference was statistically significant（P<0.05）. The levels of BMI,SBP,TG,TC,LDL-C,FBG and UA in group A were higher than those in group B,and the differences were statistically significant（all P<0.05）. The multivariate logistic regression analysis showed that the increase of TC and UA might be the influencing factors of HP infection. Conclusion The prevalence rate of HP infection and dyslipidemia is high in the occupational health examination population,HP infection is closely related to dyslipidemia,therefore,joint prevention and control of related diseases should be improved.

Key words: Occupational population, Helicobacter pylori, Dyslipidemia, Correlation

中图分类号:

R181.3

李念念, 张平安. 职业人群幽门螺杆菌感染与血脂异常的相关研究. [J]职业与健康, 2023, 39(6): 779-783.

LI Nian-nian, ZHANG Ping-an. Study on correlation between Helicobacter pylori infection and dyslipidemia in occupational population. [J]OCCUPATION AND HEALTH, 2023, 39(6): 779-783.

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