猴痘背景下艾滋病的防治策略研究进展

摘要/Abstract

摘要： 艾滋病是因患者感染人类免疫缺陷病毒（human immunodeficiency virus,HIV）所引起的综合征,至今尚无有效防治手段,被称为超级恶性肿瘤。猴痘是由猴痘病毒（monkeypox virus,MPOX）感染所致的病毒性人畜共患病,从2022年开始至今猴痘病毒在全球范围内快速传播。猴痘和艾滋病具有相似的传播途径和高危感染人群,使得患者同时感染2种疾病的概率上升,猴痘的流行给艾滋病患者带来极大压力。本文对艾滋病合并猴痘患者的感染现状、传播途径、感染人群以及当前的预防和治疗手段进行综述,以期对艾滋病合并猴痘患者的预防和治疗提供参考。

关键词: 艾滋病, 猴痘, 预防和治疗, 疫苗

Abstract: Acquired immune deficiency syndrome（AIDS） is a syndrome caused by human immunodeficiency virus（HIV） infection, and there is no effective means of prevention and treatment,so it was called super cancer. Monkeypox is a viral zoonosis caused by monkeypox virus（mpox） infection,which has been rapidly spreading worldwide since 2022. Monkeypox and AIDS share similar routes and groups of infections,which result in increasing risks for patients who infected with both diseases,monkeypox epidemic brought critical challenges to patients with AIDS. This article reviews the infection status,transmission routes,infected population,and current prevention and treatment methods of AIDS monkeypox patients,and point out problems we are facing now,in order to provide reference for the prevention and treatment of AIDS monkeypox patients in the future.

Key words: Acquired immune deficiency syndrome, Monkeypox, Prevention and treatment, Vaccine

中图分类号:

R181.3

朱沭奕, 万彬, 肖旭珏, 张春兰, 曹文娟, 金燕. 猴痘背景下艾滋病的防治策略研究进展. [J]职业与健康, 2025, 41(13): 1849-1853.

ZHU Shuyi, WAN Bin, XIAO Xujue, ZHANG Chunlan, CAO Wenjuan, JIN Yan. Research progress on prevention and treatment strategies of AIDS under the background of monkeypox. [J]OCCUPATION AND HEALTH, 2025, 41(13): 1849-1853.

参考文献

[1] 王长泰,刘林娜,赵令斋,等.《猴痘诊疗指南(2022年版)》解读[J].新发传染病电子杂志,2022,7(3):12-17.
[2] World Health Organization.Clinical management and infection prevention and control for monkeypox:Interim rapid response guidance[R/OL].(2022-06-10)[2023-06-16].https://apps.who.int/iris/bitstream/handle/10665/355798/WHO-MPX-Clinical_and_IPC-2022.1-eng.pdf?sequence=1&isAllowed=y.
[3] 张成龙,康殿民.猴痘在男男性行为者人群中的流行与干预[J].预防医学论坛,2023,29(6):474-476,480.
[4] HE N A.Research progress in the epidemiology of HIV/AIDS in China[J].China CDC Wkly,2021,3(48):1022-1030.
[5] TOSHKOV D I,ANDREEVA Y S,MLADENOVA R A,et al.Antivirals for the treatment of monkeypox:Utilization in the general and HIV-positive population and gaps for research.A short narrative review[J].Infez Med,2023,31(2):186-194.
[6] SCOTT P,MARK R B.A review of experimental and natural infections of animals with monkeypox virus between 1958 and 2012[J].Future Virol,2013,8(2):129-157.
[7] 汪洁英,宁博,曹莹,等.猴痘的研究进展及防控对策[J].中国人兽共患病学报,2023,39(7):631-638.
[8] TREVON F,HENRI A T,PRIME M M,et al.Using remote sensing to map the risk of human monkeypox virus in the congo basin[J].Eco Health,2011,8(1):14-25.
[9] 赵敏,付环茹,李家玉,等.猴痘病毒研究进展[J].动物医学进展,2023,44(6):101-105.
[10] UNAIDS.The path that ends AIDS:UNAIDS global AIDS update 2023[R/OL].(2023-07-14)[2023-08-14].https://www.unaids.org/en/resources/documents/2023/global-aids-update-2023.
[11] KHALID S A,GAMAL M M,ABDELAZIZ E D,et al.Monkeypox(mpox) in immunosuppressed patients[J].F1000Res,2023,12:127.
[12] CURRAN K G.HIV and sexually transmitted infections among persons with monkeypox-Eight US Jurisdictions,May 17-July 22,2022[J].MMWR Morb Mortal Wkly Rep,2022,76(36):1141-1147.
[13] IAS.IAS2023 highlights advances in HIV prevention,treatment and cure research[R/OL].(2023-07-20)[2023-08-16].https://www.iasociety.org/news-release/ias-2023-highlights-advances-in-hiv-prevention-treatment-and-cure-research.
[14] LENA W,JOSE A J G,LAURA B,et al.Clinical presentation of monkeypox among people living with HIV in south florida:A case series[J].Infez Med,2022,30(4):610-618.
[15] 姜婷婷,陈祥生.全球猴痘流行状况及趋势[J].中国麻风皮肤病杂志,2023,39(7):535-537.
[16] NARJES B,ZAHRA K,NASIM K,et al.Educational needs assessment of medical and midwifery students about prevention of mother-to-child transmission of HIV:A cross-sectional study[J].Virus Dis,2023, 34(2):270-277.
[17] KOZLOV M A X.Monkeypox outbreaks:4 key questions researchers have[J].Nature,2022,606(7913):238-239.
[18] World Health Organization.Mpox(monkeypox)[EB/OL].(2023-04-18)[2023-06-16].https://www.who.int/en/news-room/fact-sheets/detail/monkeypox.
[19] European Centre for Disease Prevention and Control,WHO Regional Office for Europe.Mpox,joint epidemiological overview[EB/OL].(2023-06-06)[2023-06-16].https://monkeypoxreport.ecdc.europa.eu/.
[20] European Center for Disease Prevention and Control.Factsheet for health professionals on mpox(monkeypox)[EB/OL].(2023-06-01)[2023-06-16].https://www.ecdc.europa.eu/en/all-topics-z/monkeypox/factsheet-health-professionals.
[21] 槐鹏程,侯建玲,孙远航,等.猴痘二例报道并流行特征分析[J].中国麻风皮肤病杂志,2023,39(9):629-630.
[22] 赵红洋. 国内外艾滋病流行现状及防控研究进展[J].世界最新医学信息文摘,2019,19(20):72-73.
[23] 中华人民共和国国务院公报.国务院办公厅关于印发中国遏制与防治艾滋病“十三五”行动计划的通知[EB/OL].(2017-07-17)[2023-08-15].https://www.gov.cn/gongbao/content/2017/content_5171331.htm.
[24] GUANQIAO L,YAN J,LINQI Z.HIV upsurge in China's students[J].Sci NY,2019,364(6442):711.
[25] The Well Project.Teens and HIV Prevention:What parents and providers need to know[EB/OL].(2023-09-24)[2023-09-30].https://www.thewellproject.org/hiv-information/teens-and-hiv-prevention-what-parents-and-providers-need-know.
[26] JOHN T P,SAPHA B,SHARON W,et al.Monkeypox virus infection in humans across 16 countries-April-June 2022[J].N Engl J Med,2022, 387(8):679-691.
[27] ANDRÉS F H,CHLOE O M,BOGHUMA T K,et al.Hospitalization risk among patients with mpox infection-A propensity score matched analysis[J].Ther Adv Infect Dis,2023,10:20499361231196683.
[28] 马婧怡. 男男性行为者身份认同对高危性行为研究[D].南京:南京邮电大学,2023.
[29] MAUREEN M J,SHAMA C,GRACE M E,et al.Severe monkeypox in hospitalized patients-United states,August 10-October 10,2022[J].MMWR Morb Mortal Wkly Rep,2022,71(44):1412-1417.
[30] EDWARD B A,ALLISON N L.Smallpox vaccine:The good,the bad,and the ugly[J].Clin Med Res,2003,1(2):7-92.
[31] 王天姿,初同胜,槐鹏程,等.以冠状沟斑块为首发表现的猴痘一例报道并文献复习[J].中国麻风皮肤病杂志,2023,39(8):551-554.
[32] ABDELMOEZ R F,RANJIT S,A A E,et al.Human monkeypox disease(MPX)[J].Infez Med,2022,30(3):372-391.
[33] 国家卫生健康委办公厅.《猴痘防控方案》[EB/OL].(2023-07-26)[2023-08-10].http://www.nhc.gov.cn/yjb/s3577/202207/acd6016aaca543e29c16deb9b5ea3303.shtml.
[34] World Health Organization.Vaccines and immunization for monkeypox:Interim guidance[R/OL].(2022-11-16)[2023-06-16].https://www.who.int/publications/i/item/WHO-MPX-Immunization-Annexes-2022.
[35] ABDELAZIZ A,ABDULLAH R,ISMAIL B L,et al.Preventing the next pandemic:Is live vaccine efficacious against monkeypox,or is there a need for killed virus and mRNA vaccines?[J].Vaccines,2022, 10(9):1419.
[36] 赵方,李在村,赵红心,等.2023 HIV抗病毒治疗二联简化疗法专家共识[J].中国艾滋病性病,2023,29(5):499-508.
[37] AIKATERINI A,YUJIE L,BRIAN W.Cellular reservoirs of HIV-1 and their role in viral persistence[J].Cur HIV Res,2008,6(5):388-400.
[38] 虞晓云. 艾滋病患者药学服务模式探讨及治疗效果评价[D].镇江:江苏大学,2022.
[39] OJEWOLE E,MACKRAJ I,NAIDOO P,et al.Exploring the use of novel drug delivery systems for antiretroviral drugs[J].Eur J Pharm Biopharm, 2008,70(3):697-710.
[40] WILL D,MICHAEL N R,NEIL S T,et al.HIV excision utilizing CRISPR/Cas9 technology:Attacking the proviral quasispecies in reservoirs to achieve a cure[J].MOJ Immunol,2014,1(4):00022.
[41] 周小毅,周紫月,石璇,等.老年人艾滋病干预研究进展[J].中国艾滋病性病,2023,29(8):939-942.
[42] OSCAR A A,RAPHAËL P,MATTHIEU P,et al.Chimeric antigen receptor T-cell therapy for HIV cure[J].Curr Opin HIV AIDS,2021,16(2):88-97.
[43] KRISTEN W C,ROSA D S C,WILLIAM F J.A first-in-human germline-targeting HIV nanoparticle vaccine induced broad and publicly targeted helper T cell responses[J].Sci Transl Med,2023,15(697):eadf3309.
[44] JESSE O,THOMAS D F,SAPNA B M,et al.Interim guidance for prevention and treatment of monkeypox in persons with HIV infection- united states,August 2022[J].MMWR Morb Mortal Wkly Rep,2022, 71(32):1023-1028.
[45] SHANGYU Y,YONG W,FEIYANG Y,et al.Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2[J].Nat Commun,2023,14(1):5186.