基于CiteSpace的抗肿瘤药物相关职业暴露的文献计量学和可视化分析

摘要/Abstract

摘要： 目的通过文献计量学方法分析 Web of Science（WOS）核心合集数据库中近20年抗肿瘤药物职业暴露相关研究的热点和发展趋势,为后续深入研究该领域提供参考。方法从 Web of Science 核心数据库中检索2004年1月1日—2024年4月14日抗肿瘤药物职业暴露相关的文献,使用CiteSpace 软件对这一领域文献进行发文量分析、参考文献爆发分析以及关键词分析。结果筛选后得到 325 篇文献,抗肿瘤药物职业暴露相关文献年发文量总体呈波动上升态势。关键词词频前3位为职业暴露（241篇）、抗肿瘤药物（134篇）和环磷酰胺（101篇）;对关键词聚类分析共得到10个聚类,包括清洁、淋巴细胞、环境污染和职业病危害等。发文量前5位的国家有意大利、美国、法国、加拿大和日本。结论抗肿瘤药物相关职业暴露研究发文量总体呈增长缓慢的趋势,其中抗肿瘤药物环境残留监测、过程监控与健康风险评估等发文量较大,且发文国家多为发达国家。当前肿瘤发病率逐年上升,医护人员处理抗肿瘤药物的数量及时间也随之增加,应提高医务人员对抗肿瘤药物职业安全方面的管理意识。

关键词: 抗肿瘤药物, 职业暴露, 文献计量学, 可视化分析

Abstract: Objective To analyze the hotspots and development trends of studies on occupational exposure to antineoplastic drugs in the Web of Science（WOS） core collection database over the past 20 years to provide a reference for subsequent in-depth investigations in this field. Methods Articles on occupational exposure to antineoplastic drugs from January 1,2004 to April 14,2024 were retrieved from the Web of Science core collection database. Cite Space software was used to conduct analysis of publication volume,reference explosion,and keyword frequency in this field. Results After screening,325 articles were obtained,and the overall annual publication volume of articles related to occupational exposure to anti-tumor drugs showed a fluctuating upward trend. The top three keywords in terms of frequency were "occupational exposure"（241）,antineoplastic drugs"（134）,and "cyclophosphamide"（101）.Through keyword cluster analysis,10 clusters were identified,covering topics such as cleanliness,lymphocytes,environmental pollution,and occupational disease hazards. The top five countries with the highest number of publications were Italy,the United States,France,Canada,and Japan. Conclusion The overall number of publications on occupational exposure related to antineoplastic drugs shows a slow growth trend,with a large number of publications on environmental residue monitoring,process monitoring,and health risk assessment of antineoplastic drugs,and the publishing countries are mostly developed countries. Currently,the incidence rate of cancer is rising year by year,and the number and duration of medical staff handling antineoplastic drugs are also increasing,so the management awareness of occupational safety of antineoplastic drugs should be improved for the medical staff.

Key words: Antineoplastic drug, Occupational exposure, Bibliometric analysis, Visualization analysis

中图分类号:

R181.2

梁恒娟, 杨博, 黄小红. 基于CiteSpace的抗肿瘤药物相关职业暴露的文献计量学和可视化分析. [J]职业与健康, 2025, 41(14): 1985-1992.

LIANG Hengjuan, YANG Bo, HUANG Xiaohong. Bibliometric and visual analysis of occupational exposure related to antineoplastic drugs based on CiteSpace. [J]OCCUPATION AND HEALTH, 2025, 41(14): 1985-1992.

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